Endocrine Abstracts

Psychological mental stress is associated with poor glycemic control in type 2 diabetes mellitus. The aim of this study is to exam the effect of psychological mental stress on glycemic control during short-term admission for diabetic educational program in type 2 diabetic patients. This study was carried out in 18 type 2 diabetic patients aged 44–82 years who were shortly admitted for diabetic educational program in our hospital. We measured salivary alpha-amylase activit...

Fragile bone fractures due to deteriorating bone quality are increased in patients with type 2 diabetes mellitus. This study aimed to measure serum levels of pentosidine and adipocytokines, e.g. adiponectin and leptin, and compare between those biochemical markers and bone mineral density of lumber in patients with type 2 diabetes mellitus. Serum concentration of adiponectin, leptin and pentosidine was measured in 19 type 2 diabetic patients (mean age 65.9+2.3 years) and 13 no...

Rheumatoid arthritis (RA) is a chronic inflammatory disease that results in generalized bone loss and increased fracture risk. Although glucocorticoids are frequently prescribed for the symptomatic management of inflammatory disorders such as RA, extended glucocorticoid exposure is the leading cause of osteoporosis and leaves patients at a high risk of fracture. The aim of this study is to evaluate the efficacy and safety of monthly oral minodronate for the treatment of osteop...

Glucocorticoid-induced osteoporosis is the most common form of secondary osteoporosis. Glucocorticoid is known to cause hyperparathyroidism due to parathyroid hormone (PTH) secretion. In addition, glucocorticoid and PTH have also been reported to induce RANKL mRNA expression in osteoblasts and promote osteoclastogenesis. However, little is known about cooperative effects of these hormones. The purpose of this study was to clarify the regulation of RANKL mRNA expression by gluc...